RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
CDKN2A
RNA ID
RNA Type
mRNA
Alteration Pattern
dna hypermethylation
Species
homo sapiens
Detection Methods
Genomic DNA digestion and promoter amplification; qRT-PCR; etc.
Target
NA
Pathway
NA
PubMed ID
Title
Hypermethylation-mediated silencing of p14(ARF) in fibroblasts from idiopathic pulmonary fibrosis
Year
2012
Function
"IPF fibroblasts have reduced expression of the proapoptotic p14(ARF) attributable to promoter hypermethylation, wand the p14(ARF)-hypermethylated IPF fibroblasts were significantly more resistant to staurosporine-and S-nitrosoglutathione-induced apoptosis compared with normal and nonmethylated IPF fibroblasts (P < 0.01) And showed reduced levels of p53."